Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal Treatment

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Objectives: The aim of the present clinical study was to evaluate the efficacy of doxycyline 3% plus ketoprofen 2.5% as an adjunct to scaling and root planing in the treatment of chronic periodontitis(early-modearte). Material and Methods: 20 systemically healthy, chronic periodontitis patients were included in the study.The Patients were selected on the basis of having chronic periodontitis with periodontal pocket depths of more than 4mm on at least two teeth in mandibular molar area; Periodontal parameters (plaque, bleeding on probing and pocket depth) were recorded at baseline and every 15 days for 3 months. Oral hygiene instructions were given that included brushing twice- daily, (Using the Bass brushing technique for at least 2 minutes ), Randomly divided two groups,Test group: was treated by scaling and root planing Followed by local delivery of doxycycline 3%+ ketoprofen 2.5%, While the control group: was treated by scaling and root planing along with ketoprofen 2.5%; and was administered to the both groups every 15 days for 3 months, repeated. Every 15 days once periodontal parameters were assessed, and at the end of 3 months, evaluated the clinical parameters changes.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Islamic Azad University, Tehran
• Treatments: Doxycycline; Insulin; Insulin, Globin Zinc; Ketoprofen

Criteria

Inclusion Criteria:

• adult patients,

• older than 18 years old,

• systemically healthy, and

• having at least 20 teeth.

Exclusion Criteria:

• patients with cavitated caries,

• no periodontal pockets larger than 4 mm,

• orthodontic appliances or removable prostheses,

• allergies to cetylpyridinium or CHX,

• use of antibiotics and anti-inflammatory drugs in the past 3 months that might alter normal gingival health,

• oral prophylaxis outside of study;

• use of oral chlorhexidine products or participation in an oral rinse study within 3 months prior to baseline examination,

• pregnancy or lactation,

• smoking.