Efficacy of Sublingual Versus Subcutaneous Allergen Immunotherapy in Patients With Bronchial Asthma
Status:
Completed
Trial end date:
2023-03-10
Target enrollment:
Participant gender:
Summary
Asthma is characterized by airway inflammation and is manifested by acute episodes of
obstruction related to loss of control of airway inflammation mostly in response to a viral
respiratory tract infection .The significance of eosinophilic inflammation in asthma is well
established.
Late clinical reactions in asthma are associated with increase of immunoglobulin E (IgE) in
serum. Serum IgE can be used as a measure of allergen provocation causing increased
eosinophil activity. Serum IgE can be used to assess the exposure to environmental allergens,
or decreasing presence of allergen in the environment and the need for increase or reduction
of therapy.
Allergen immunotherapy is defined as the repeated administration of specific allergens to
patients with IgE-mediated conditions for the purpose of providing protection against the
allergic symptoms and inflammatory reactions associated with natural exposure to these
allergens.
The aim of this work is to evaluate the effect of sublingual versus subcutaneous allergen
immunotherapy as regard clinical response, serum IgE and sputum eosinophils