Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Septic shock is a clinical condition that is defined as a subset of sepsis that causes very high mortality and morbidity.

Surviving sepsis campaign guideline states that the target mean arterial pressure should be 65 mmHg and above in septic shock patients. It is known that abdominal pressure increases and perfusion of intra-abdominal organs decreases in septic shock patients.

With this study, we aim to investigate the effects of targeted abdominal perfusion pressure (60 mmHg and above) on renal injury, reversal of renal injury, liver functions and ultimately mortality in patients with septic shock.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bozyaka Training and Research Hospital
• Treatments: Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Diagnosis of septicemia according to "Surviving Sepsis Campaign Guidelines 2021"

• Age lower than 18

Exclusion Criteria:

• Reason of admission: Cardiac arrest

• Pregnancy

• Abdominal surgery in the past 90 days

• Pre-diagnosis of end-stage renal disease

• History of abdominal trauma

• Body mass index of 30 and above

• Trauma, bleeding or cerebrovascular event that causes increased intracranial pressure