Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

• Status: Not yet recruiting
• Trial end date: 2023-02-25
• Target enrollment: 0
• Participant gender: All

Summary

To explore the effect of commonly used antiemetic drugs on reducing nausea and vomiting caused by intravenous tramadol injection, so as to reduce the incidence of nausea and vomiting in clinical use of tramadol and provide guidance for the clinical use of tramadol injection

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University
• Treatments: Dexamethasone; Metoclopramide; Tropisetron

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists classification I-II

• 18.5≤BMI≤28

• Patients who require general anesthesia and recieve PCIA

• Volunteerly and be able to understand and sign the informed consent form

Exclusion Criteria:

• Long-term use of analgesics, psychotropic drugs (including opioids, NSAIDS, antidepressants) history

• History of allergy to opioids

• Patients with a history or family history of epilepsy that has not been controlled by treatment

• Sedatives and antidepressants were used 24 hours before surgery

• Failure to cooperate with the study for any reason or in the opinion of the investigator