Efficacy of Topical Calcipotriol-assisted AFL-PDT in Actinic Keratosis

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin D(Vit D) is a pro-differentiation agent that enhances the accumulation of protoporphyrin IX (PpIX) after MAL(methyl-aminolevulinate) incubation in actinic keratosis and may have significant benefit for the treatment of actinic keratosis by ablative fractional laser-primed photodynamic therapy (AFL-PDT).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dong-A University
• Treatments: Calcipotriene; Calcitriol; EMLA; Ergocalciferols; Lidocaine; Lidocaine, Prilocaine Drug Combination; Prilocaine; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Korean patients aged ≥ 18 years who had biopsy-confirmed Actinic keratosis lesions

Exclusion Criteria:

• calcium metabolic disorder patients

• photosensitivity disorder patients

• lactating or pregnant women

• patients with porphyria or a known allergy to any of the constituents of the MAL cream and lidocaine

• patients with systemic disease, history of malignant melanoma, tendency of melasma development or keloid formation, any AK treatment of the area in the previous 4 weeks, or any conditions associated with a risk of poor protocol compliance; and patients on immunosuppressive treatment