Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
The investigators want to study the effect of clobetasol in symptomatic oral lichen planus.
The investigators will include 90 patients and randomly alocate them in three groups. The
frist group will recive active treatment both in the morning an evening. Group two recieves
palcebo in the morning and active treatment in the evening. Group three will get palcebo both
in the morning and in the evening. All Groups will follow the same protocol with rinsing
twice daily with clobetasol in conjunction with antfungal treatment. The patients will be
controlled after two weeks and and again after another two weeks. A biopsy will be performed
at inclusion and another biopsy will be taken at the end of the testperiod. Smears for
candida will also be evaluated. The patients will be examined for change in clinical
apearance and will answer questions to note changes in symptoms. Our hypothesesis: #Patients
recieving clobetasolrinses will have a better resolution af symptoms than those who got
placebo. #Patients treated with clobetasol twice daily will have a faster relief of symptoms
than patients just teated once daily. #The clinical signs of oral lichen planus will diminish
more pronounced in the two groups given active treatment. #A majority of the OLP lesions were
infected by candida. #Specific histological changes can be seen in the biopsies taken after
clobetasoltreatment compared to those taken before treatment.