Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to compare the effects of two bolus doses of intravenous remifentanil given prior to the emergence of anesthesia:

• on the incidence of perioperative coughing

• on the time needed for the emergence of a desflurane-based anesthesia

• on the incidence of sore throat after extubation.

The investigators hypothesis is that the use of a higher remifentanil bolus dose (0.5 mcg/kg) given prior to emergence of a desflurane-based anesthesia will reduce the incidence of perioperative coughing when compared to a lower dose of remifentanil (0.25 mcg/kg).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Collaborator: Centre de Recherche du Centre Hospitalier de l'Université de Montréal
• Treatments: Anesthetics; Remifentanil

Criteria

Inclusion Criteria:

• Patients aged 18-80 years

• Physical status 1-3

• Patients undergoing elective surgery under general anesthesia requiring endotracheal intubation (excluding head and neck surgery)

Exclusion Criteria:

• Current use of ACE inhibitors

• Chronic cough

• Asthma or severe pulmonary disease

• Pulmonary tract infection

• Anticipated difficult intubation

• Current use of opioids

• Current use of cough medicine

• Contraindication to remifentanil

• Pregnancy

• Symptomatic cardiac, renal or hepatic disease