Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy

• Status: Completed
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic retinopathy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Guadalajara
• Collaborator: Instituto Mexicano del Seguro Social
• Treatments: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Coenzyme Q10; Copper; Tocopherols; Tocotrienols; Ubiquinone; Vitamin E; Vitamins

Criteria

Inclusion Criteria:

• Patients with type 2 diabetes mellitus

• Patients with non proliferative diabetic retinopathy

• Glycated hemoglobin < 12.0%

• Signing of informed consent

Exclusion Criteria:

• Patients with clinically significant macular edema

• Patients with diabetic retinopathy advanced lesions that have required or require specific treatment (laser, vitrectomy)

• Pretreatment with argon laser or excimer laser Ophthalmology surgery

• Any other associated ocular pathology (glaucoma, cataracts, changing cornea dystrophy, macular degeneration)

• Pregnancy, lactation, inadequate use of contraception

• Antioxidant drug and/or supplements six months previous to enrollment

• Renal and/or hepatic failure

• Age under 30 or over 75 years

• Severe cardiovascular disease (myocardial infarction, stroke, severe peripheral vasculopathy)

• Blood dyscrasias

• Have or have had cancer or other serious illness

• Neurodegenerative process

• Allergy to vitamins