Overview
Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder
Status:
Completed
Completed
Trial end date:
2016-03-01
2016-03-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study aims at evaluating the effect of vortioxetine on cognitive dysfunction in major depressive disorder (MDD) patients with inadequate response to current antidepressant treatment.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
H. Lundbeck A/STreatments:
Antidepressive Agents
Citalopram
Dexetimide
Vortioxetine
Criteria
Inclusion Criteria:- The patient has MDD, diagnosed according to DSM-IV-TR™ recurrent MDE (classification
296.3x) as confirmed using the Mini International Neuropsychiatric Interview (MINI).
- The patient has depressive symptoms currently considered as non- or only partially
responsive (inadequate response), to one adequate course of SSRI/SNRI antidepressant
monotherapy and is candidate for a switch in the investigator's opinion.
- The patient wants to stop taking his/her current SSRI/SNRI treatment due to inadequate
response confirmed by the Antidepressant Treatment Response Questionnaire (ATRQ), <50%
response to current treatment).
- The patient must have been treated by SSRI/SNRI monotherapy (citalopram, paroxetine,
sertraline, duloxetine, or venlafaxine) for at least 6 weeks at licensed doses prior
to the Screening Visit.
- The patient has a PHQ-9 total score ≥14.
- The patient has a MADRS total score ≥ 22.
- The patient has had the current MDE for ≤1 year.
- The patient has a Perceived Deficits Questionnaire - Depression (PDQ-D) total score
>25.
- The patient is a man or woman aged ≥18 and ≤65 years.
Exclusion Criteria:
- The patient has a score ≥70 on the DSST (Number of Correct Symbols) at the Baseline
Visit.
- The patient has physical, cognitive, or language impairment of such severity as to
adversely affect the validity of the data derived from the neuropsychological tests.
- The patient has any current psychiatric disorder or Axis I disorder (according to
DSMIV-TR™ criteria) other than MDD, as assessed using MINI.
- The patient has a current or has had a diagnosis of dysthymic disorder within 3 months
preceding the onset of current episode (DSM-IV-TR™ criteria).
- The patient has borderline, schizotypal, schizoid, paranoid, histrionic, antisocial
personality disorders (axis II) as comorbid or primary diagnosis (DSM-IV-TR™
criteria).
- The patient has history of previous MDEs considered as treatment resistant defined as
inadequate response (incomplete or no therapeutic response) to two prior courses of at
least 6 weeks of conventional antidepressant drugs in adequate dosages or, the patient
has treatment-resistant depression in the investigator's judgement.
- The patient suffers from personality disorders, mental retardation, pervasive
development disorder, attention-deficit/hyperactivity disorder, organic mental
disorders, or mental disorders due to a general medical condition (DSM-IV-TR™
criteria).
- The patient has a diagnosis of alcohol or other substance abuse or dependence
(excluding nicotine or caffeine) (DSM-IV-TR™ criteria) that has not been in sustained
full remission at least 2 years prior to the Screening Visit.
- The patient has a current diagnosis or history of manic or hypomanic episode,
schizophrenia or any other psychotic disorder, including major depression with
psychotic features (DSM-IV-TR™ criteria).
Other protocol defined inclusion and exclusion criteria may apply.