Efficacy of a Probiotic Lozenge (Inersan) in Patients With Chronic Periodontitis
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
Periodontal disease is a major cause of tooth loss in humans and is one of the most prevalent
diseases associated with bone loss. Following bacterial colonization, the gingiva becomes
inflamed leading, in some cases, to the destruction of the alveolar bone. Periodontitis has
two distinct but interconnected etiologic components, periodontopathic bacteria and
host-mediated connective tissue-destructive responses to the causative bacteria and their
metabolic products.
A few studies have revealed that probiotic Lactobacillus strains were useful in reducing
gingival inflammation and the number of black-pigmented rods, including Porphyromonas
gingivalis (Pg), in the saliva and sub-gingival plaque. Concerning periodontal conditions,
its shown that application of beneficial bacteria, as an adjunct to scaling and root planing
(SRP), can inhibit re-colonization of pathogens in periodontal pockets and reduce bleeding on
probing.
The aim of the present study is to evaluate the improvement of periodontal health with
probiotic (Inersan) lozenges, used as an adjunct to scaling and root planing [SRP].
Phase:
Phase 3
Details
Lead Sponsor:
CD Pharma India Pvt. Ltd.
Collaborator:
Mahatma Gandhi Post-Graduate Institute of Dental Sciences