Efficacy of an Early Antipsychotic Switch in Case of Poor Initial Response to the Treatment of Schizophrenia

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The main aim of the trial is to study whether a change of medication in non-responders to a two-weeks antipsychotic drug trial is more effective than continued treatment with the same antipsychotic. Hypothesis: Non-responders who are switched at 2 weeks to another antipsychotic are more frequently in symptomatic remission at week 8 than non-responders who stay on the same antipsychotic

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität München
• Treatments: Amisulpride; Antipsychotic Agents; Olanzapine; Sulpiride; Sultopride

Criteria

Inclusion Criteria:

• Inpatients with DSM-IV TR diagnosis of schizophrenia, schizophreniform or schizoaffective disorder

• PANSS total score at baseline > 75, at least two PANSS psychosis items ≥ 4, Clinical Global Impression of severity score moderately ill or more (≥4)

• Increase in the level of care (outpatient care to day clinic or inpatient care)

Exclusion Criteria:

• contraindication to study drugs