Efficacy of the Chronic Application of Tear Formulations

• Status: Unknown status
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the therapeutic effect of the chronic application of eye-drops on tear evaporation rate in dry eye and normal subjects exposed to a condition of environmental stress. The effect will be studied in terms of changes in tear physiology and the inflammatory biomarkers on the ocular surface.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Glasgow Caledonian University
• Collaborator: Allergan
• Treatments: Glycerol

Criteria

Inclusion Criteria:

• Be between the ages of 18 and 79 years of age.

• Must understand and be able, willing and likely to fully comply with study procedures and restrictions.

Exclusion Criteria:

• Active ocular allergy

• Current contact lens wear

• Any topical ophthalmic drops within 1 week of initial screening visit.

• Started or changed the dose of chronic systemic medication known to affect tear production including, but not limited to antihistamines, antidepressants, diuretics, corticosteroids or immunomodulators within 30 days of initial screening visit.

• Systemic disease known to affect tear production or loss including, but not limited to thyroid eye disease, that has been diagnosed or has not been stable within 30 days initial of screening visit.

• Known hypersensitivity to any of the agents used in testing.