Efficay and Safety of Empagliflozin Versus Sitagliptin for the In-patient Management of Hyperglycemia
Status:
Recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
Clinical guidelines from professional organizations have recommended the use of multidose
insulin regimens as the preferred therapy for glycaemic control in patients admitted to
hospital in a non-intensive-careunit setting. The use of a basal-bolus regimen with a once
daily basal insulin and rapid-acting insulin analogs before meals has been shown to improve
glycaemic control and to reduce the rate of hospital complications in general medical and
surgical patients with type 2 diabetes.The basal-bolus regimen however is labour intensive,
requiring several insulin injections, and is associated with a high risk of hypoglycaemia.
Hypoglycaemia has been reported in 12% to 32% of patients in general medicine and surgery
with type 2 diabetes treated with basal-bolus insulin regimens.Because of these limitations,
alternative treatment regimens are needed that could improve glycaemic control and clinical
outcomes, while facilitating care and minimising the risk of hypoglycaemia in patients with
diabetes.