Electronic Training of Elderly Depression With Cognitive Impairment

• Status: Recruiting
• Trial end date: 2023-08-18
• Target enrollment: 0
• Participant gender: All

Summary

late-life depression (LLD) is the most common mental illness in the elderly. Due to the increasing prevalence of population aging, it has become one of the important factors affecting the quality of life of the elderly. 50-70% of elderly patients with depression are accompanied by different degrees of cognitive impairment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Capital Medical University
• Treatments: Citalopram; Fluoxetine; Fluvoxamine; Paroxetine; Serotonin; Serotonin Uptake Inhibitors; Sertraline

Criteria

Inclusion Criteria:

1. The patients and their family members signed the written informed consent

2. Age ≥60 years old

3. Meet the diagnostic criteria for single or recurrent major depressive disorder in the diagnostic and Statistical Manual of mental disorders Fourth Edition (DSM-V)

4. Currently in the acute phase, HAMD-17 total score at baseline ≥ 18 points

5. There are symptoms of cognitive impairment, Montreal Cognitive Assessment scale (Montreal Cognitive Assessment scale, MoCA) <26 points

6. Education level above primary school.

Exclusion Criteria:

1. Patients with history of epilepsy or coronary heart disease or other serious unstable physical diseases

2. Participated in another intervention clinical study in the past 1 month

3. The following mental diseases have been or are currently diagnosed by DSM-V: organic mental disorder, Alzheimer's disease, secondary dementia caused by other causes, schizophrenia, schizophrenic affective disorder, bipolar disorder, delusional disorder, undefined mental disease, patients with drug abuse history, including alcohol and active drug abuse in the past 12 months, except nicotine

4. He has been taking antidepressants, mental retardants and other psychiatric drugs for the past 2 weeks

5. Severe aphasia, visual and hearing impairment, etc. unable to complete the scale evaluation