Electrophysiological Effects of Late PCI After MI

• Status: Completed
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if opening blocked arteries with heart balloons and stents prevents heart rhythm problems in individuals 3 to 28 days after a heart attack.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Heart, Lung, and Blood Institute (NHLBI); University of Maryland, Baltimore
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Adrenergic Agents; Adrenergic Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Platelet Aggregation Inhibitors

Criteria

Inclusion Criteria:

• Has experienced a heart attack 3 to 28 days prior to study entry

• Persistently occluded IRA defined as either: 1) Thrombolysis in Myocardial Infarction (TIMI) 0, with no flow beyond the site of occlusion; or 2) TIMI 1, with penetration of dye beyond the site of occlusion without dye reaching the distal vessel

• LVEF less than 50% or proximal occlusion in a large vessel

• Normal sinus rhythm

• QRS duration less than 120 ms

• Able to return for follow-up assessment of arrhythmia markers one month and one year after study entry

Exclusion Criteria:

• Has a clinical indication for revascularization (post-heart attack angina at rest; significant inducible ischemia; or significant left main or triple vessel disease requiring PTCA or CABG)

• Current serious illness or condition that limits 3-year survival

• Severe valvular disease

• Chronic total occlusion

• New York Heart Association Class III-IV congestive heart failure

• Prior left ventricular aneurysm in the recent heart attack location

• Is a poor candidate for PTCA/stent on the basis of angiographic or clinical criteria

• Cannot medically survive anticoagulation during PTCA/stent or antiplatelet therapy after stent

• Pregnant