Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma

• Status: Completed
• Trial end date: 2014-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates whether some patients with nasopharyngeal carcinoma but with low risk of distant metastasis can be treated with only radiotherapy and concomitant chemotherapy but without additional adjuvant chemotherapy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-sen University
• Treatments: Cisplatin; Fluorouracil

Criteria

Inclusion Criteria:

• (1) biopsy-proven carcinoma of the nasopharynx,

• (2) AJCC 1997 Stage II (T2aN0, T1-T2aN1) or III (T1-T2aN2) disease,

• (3) normal renal function (Cr < 1.6 mg/dl),

Exclusion Criteria:

• open-neck lymph node biopsy

• previous chemotherapy or radiotherapy to the head and neck region

• distant metastasis or other malignant diseases except skin cancer