Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the influence of lactulose of the human gut microbiota. Healthy volunteers will ingest 50g of lactulose and donate stool samples 1 day before as well as 1-2 days and 14 days after the test. Using sequencing and metabolomics techniques the investigators will identify changes in microbiota composition upon lactulose exposure.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Zurich
• Collaborator: Swiss Federal Institute of Technology in Zurich (ETHZ)
• Treatments: Lactulose

Criteria

Inclusion Criteria:

• Subjects free of relevant abdominal complaints (=healthy)

• Written informed consent

• Working at ETH Zurich/University of Zurich, experience in handling of -80°C freezers on biosafety level 2

Exclusion Criteria:

• Previous history of gastrointestinal disease or surgery (excludes appendectomy, hernia repair and anorectal disorders)

• Known diabetes mellitus, scleroderma, neurological impairment or other major current disease

• Subjects unable to stop medication that alters gut flora: proton pump inhibitors, laxatives and antibiotics at least 4 weeks before study entry.

• Pregnancy beyond week 12 (no pregnancy test will be performed)

• Involvement in any other clinical trial during the course of this trial, nor within a period of 14 days prior to its beginning or 14 days after its completion