Emergence Delirium in Children: Total Intravenous Anesthesia With Propofol and Remifentanil Versus Inhalational Sevoflurane Anesthesia

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Emergence delirium (ED) refers to a wide variety of behavioural disturbances that are commonly seen in children following emergence from anesthesia. ED can potentially be dangerous and have serious consequences for the child such as injury, increased pain, and dislodgement of medical devices, often requiring physical restraint or pharmacological control. Witnessing this behaviour can be stressful for parents, which can negatively affect their interaction with the healthcare system, and their relationship with the child, nursing staff and other healthcare providers. The investigators aim to minimize ED to reduce the distress experienced by patients and their parents. This study will compare the recovery profile of sevoflurane with that of propofol remifentanil and their associated incidence of ED. This study should enable us to determine which form of anesthesia is associated with the fewest incidences of ED in children.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of British Columbia
• Treatments: Anesthetics; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Children having general anesthesia for elective strabismus or other suitable minor eye surgery

• Age ≥ 2 and ≤ 6 years

• ASA I-II

• Appropriate procedure and patient for LMA airway management

Exclusion Criteria:

• Developmental delay or neurological injury

• Psychotropic medications or psychiatric diagnosis

• Abnormal lipid or carbohydrate metabolism

• Deviations from the anesthesia protocol including an inability to secure pre-anesthetic intravenous access in the TIVA group

• Severe anxiety in the pre-operative period requiring sedative. premedication according to the staff anesthesiologist's and family's assessment

• Patients experiencing pain requiring analgesia, postoperative nausea or vomiting (PONV) during the study period

• Patients seen in the pre-anesthetic assessment clinic, due to habituation to hospital environment

• Growth chart percentiles of < 3% or > 97%