Emotional Memory Reactivation in Posttraumatic Stress Disorder

• Status: Terminated
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder.

The primary purpose of our study is to assess the effect of propanolol, a beta adrenergic antagonism, on amygdala activation during a symptom provocation state in traumatized subjects with and without posttraumatic stress disorder.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Patients of French mother language

• Right-handed patients

• Signature of the consent

Patients:

• Patients whose diagnosis of PTSD according to the criteria of the DSM IV-TR is established

• PTSD whose evolution is not chronic

• Established PTSD : Symptoms presents for at least 1 month

• PTSD consecutive to a unique traumatic event

Controls :

• The healthy controls will have sudden a traumatism of the same nature or the nature comparable to that of the patients suffering from PTSD, but they will not have developed pathology

• Subjects having undergone a traumatism dating less than 3 months

• Examples of traumatic events: aggression, accident of the public highway, the occupational accident

Exclusion Criteria:

• The PTSD consecutive to several traumatic events

• Patients treated by a substance crossing the blood-brain barrier (with the exception of the antidepressants of the family of the ISRS which can be indicated in the treatment of PTSD)

• Histories of epilepsy or significant loss of consciousness of any origin, including post-traumatic

• Any psychiatric or somatic significant pathology

• The psychiatric histories in particular of suicide attempt

• The pregnant or breast-feeding women

• Contraindications in the propanolol

• Consumption of psychoactive drugs detected in urines

• Excessive alcohol consumption

• The persons not being capable of understanding or of reading the information describing the study

• The patients refusing to sign the form of consent of participation for the study

• The left-handed or ambidextrous patients

• The patients without the general regime of the health insurance

• The patients under guardianship or incapable major

• The patients who will not be capable of supplying a documentary evidence of identity the day of the inclusion

• Contraindication in the practice of a MRI

• The patients or the controls refusing the medical and psychiatric balance assessment of screening cannot participate in the study

• Strong probability of not compliance to the protocol or of abandonment in the course of study

• Taking of a speechless medicine, in particular beta-blocking

• Participating in phase of exclusion from a previous study