Empiric Versus Selective Prevention Strategies for Kidney Stone Disease

• Status: Not yet recruiting
• Trial end date: 2025-03-31
• Target enrollment: 0
• Participant gender: All

Summary

The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University Medical Center

Criteria

Inclusion Criteria:

Two or more symptomatic kidney stone events in the last 5 years adult

Exclusion Criteria:

Medullary sponge kidney or renal tubular acidosis Untreated urinary obstruction Primary hyperparathyroidism Primary hyperoxaluria Pregnancy Inflammatory bowel disease or bowel resection Sarcoidosis Cystinuria Prior stone composition with uric acid, struvite, cystine, carbonate apatite Use of specific medications (thiazides, topiramate, xanthine oxidase inhibitors, citrate, bicarbonate) Chronic kidney disease stage 3 or higher (eGFR<60) Gouty arthritis or 3 gout episodes in 1 year Known allergy to study medications Hypokalemia or hyponatremia at screening. Age < 18 years