Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis.

• Status: Completed
• Trial end date: 2018-02-19
• Target enrollment: 0
• Participant gender: Female

Summary

This study evaluates the effect in artery stiffness of enalapril maleate in Rheumatoid Arthritis women patients. Half of participants will receive 5 mg enalapril maleate every 12 hrs, while the other half will receive a placebo.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Guadalajara
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Enalapril; Enalaprilat; Enzyme Inhibitors; Maleic acid

Criteria

Inclusion Criteria:

• Patients classified with RA according to the American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) 2010

• Patients treated in the outpatient service of the Rheumatology Service of the Hospital Civil de Guadalajara "Dr. Juan I Menchaca".

• Sign an Informed Consent Letter

• Under treatment with conventional Disease-Modifying Antirheumatic Drugs (DMARDS)

Exclusion Criteria:

• Patients with a previous diagnosis of diabetes mellitus, systemic hypertension, thyroid, kidney or liver disease

• History of acute myocardial infarction, cardiac arrhythmias, cerebral vascular event or heart failure

• Smoking active patients in the last 6 months

• Patients with a desire for close conception, pregnant or breastfeeding.

• Patients with blood pressure <90/60 mmHg

• Patients who do not accept to participate in the study

• Patients with a BMI greater than ≥40 Kg / m2

• Non-palpable carotid and femoral pulses

• Unstable psychological state