Enamel Remineralization Potential of Dentifrices in Situ

• Status: Completed
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Fluorides; Fluorophosphate; Sodium Fluoride

Criteria

Inclusion Criteria:

• Good general health with (in the opinion of the investigator) no clinically significant and relevant abnormalities of medical or oral health.

• No current active caries or periodontal disease that may compromise the study or health of the subject.

• All restorations in a good state of repair

• Currently wearing a removable mandibular partial denture with sufficient room in the posterior buccal flange area to accomodate two enamel specimens required dimensions 12 x 7 mm.

• Willing to have their denture modified to accomodate enamel test specimens

• Willing and capable of wearing removable mandibular partial dentures 24 hours per day during the treatment periods.

• Salivary flow rate in the range of normal values (unstimulated whole saliva flow rate greater than or equal to 0.2 mL/ minute; gum base stimulated whole saliva flow rate greater than or equal to 0.8 mL/minute.

Exclusion Criteria:

• Individuals currently taking antibiotics, or who have taken antibiotics within 30 days prior to the first treatment visit.

• Current active caries or periodontal disease that may compromise the study or health of the subject.