Endometrial Effects of Lipiodol

• Status: Unknown status
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal is to investigate whether endometrial flushing with Lipiodol enhances fertility. Therefore, anatomo-pathological, histochemical and transcriptional changes of the endometrium after Lipiodol bathing in a general population of healthy volunteers will be determined.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitair Ziekenhuis Brussel
• Treatments: Ethiodized Oil

Criteria

Inclusion Criteria:

• Women aged ≥18 and <36 years

• Regular cycle (25-35 days)

• Signed informed consent

• Participants can be included only once in the trial

• Contraceptive: barrier method only.

Exclusion Criteria:

• known iodine allergy

• Body mass index 30 or ≤18.5

• Smoking

• Previous diagnosis of PCO (Polycystic Ovary Syndrome) (>12 antral follicles in one ovary, Rotterdam criteria 2003)

• Previous diagnosis of endometriosis, uterine malformations or intrauterine pathologies (submucosal fibroids, endometrial polyps, and intrauterine adhesions)

• Systemic diseases such as thyroid dysfunction

• Breast-feeding or pregnancy within the last 6 months

• Intrauterine devices (IUD)

• History of recurrent miscarriage

• Known history of infertility

• Previous uterine surgery

• Pregnancy wish during the course of the study

• Women who have been previously enrolled in the trial

• Those unable to comprehend the investigational nature of the proposed study