Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
This prospective randomized trial evaluates whether one can predict which infertile women
with endometriosis who are candidates for in vitro fertilization will benefit from prolonged
therapy with a GnRH agonist by the determination of the absence of endometrial expression of
the integrin, alpha v, beta 3 vitronectin. This is a prospective randomized trial in which
all patients will undergo endometrial biopsy prior to initiation of ovarian stimulation for
in vitro fertilization and then undergo randomization to a three month course of a depot
preparation of the GnRH agonist leuprolide acetate in depot suspension prior to ovarian
stimulation or standard therapy. prio