Endometrial Preparation in Frozen Embryo Transfer Cycles

• Status: Recruiting
• Trial end date: 2024-12-25
• Target enrollment: 0
• Participant gender: Female

Summary

In order to get optimal pregnancy rates after frozen embryo transfer (FET), the embryo stage and endometrium should be synchronized. Endometrial preparation is done by either natural, artificial (Hormonal replacement therapy HRT) , modified natural methods or mild ovarian stimulation. HRT cycle has a better schedualization however, there are some reports about higher rates of miscarriage, pregnancy induced hypertension (PIH) and preeclampsia (PET) in HRT cycles. A recent study has found that incorporation of the aromatase inhibitor (letrozole) to HRT cycles was associated with better FET outcomes in comparison to hormonal replacement therapy cycles alone. Meanwhile, mild ovarian stimulation protocol can be done either by oral drugs like letrozole or by letrozole plus gonadotropins . So this study aims to compare the reproductive outcomes in two endometrial preparation protocols for frozen embryo transfer cycles; letrozole mild ovarian stimulation versus HRT plus letrozole incorporation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rahem Fertility Center
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Letrozole; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Women aged between 18 and 37 years with either regular cycles or oligomenorrhoea or amenorrhoea.

• Women undergoing FET cycles.

• Participants should have at least one good-quality blastocyst available for vitrification and also for transfer after warming.

• Participants having optimal endometrium before starting luteal phase support

Exclusion Criteria:

• Women who will refuse to participate in in the study.

• Women who will not reach the optimal endometrium.

• Participants that don't have at least one good-quality blastocyst for transfer after warming.

• PGT embryos will be excluded.