Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

• Status: Unknown status
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is performed to compare the efficacy and safety of EBL, propranolol, and EBL combined with propranolol in patients with medium or large varices.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Korea University
• Treatments: Adrenergic beta-Antagonists; Propranolol; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Liver cirrhosis

• Age between 18 and 70 years

• Esophageal varices with high bleeding risk: more than F2 and red color sign

• No previous history of upper gastrointestinal bleeding

• No previous history of endoscopic, radiologic, or surgical therapy for varices or ascites

• Do not take beta-blocker, ACE inhibitor, or nitrate

• Child-Pugh score <12

Exclusion Criteria:

• Patients with systolic blood pressure <100 mmHg or basal heart rate <60/min

• Portal vein thrombosis

• Uncontrolled ascites or hepatic encephalopathy

• Severe coagulation disorder: prothrombin time <40% (or INR >1.7) or platelet count <30,000/mm3

• Medium or large sized gastric or duodenal varices

• Coexisting malignancy

• Severe cardiovascular disorder, renal failure, peritonitis, sepsis

• Severe erosive esophagitis, severe esophageal stricture, active gastric or duodenal ulcer

• Contraindication to beta-blocker

• Pregnancy

• Refusal to give consent to participate in the trial