Endoscopic Treatment of Salivary Glands Affected by Sjögren's Syndrome
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Sjögren's syndrome (SS) is an autoimmune inflammatory disorder of the exocrine glands. It
particularly affects the lacrimal and salivary glands. Severe dry mouth and eyes are
frequently reported as presenting symptoms. These symptoms are in many cases accompanied by
nonspecific symptoms, such as malaise and fatigue. In addition, extraglandular
manifestations, like purpura, polyneuropathy, and arthritis, can be present. SS affects
mainly women with a female/male ratio of 9:1 and can occur at all ages. Due to the
irreversible damage to the saliva producing cells, the quantity and quality of saliva
reduces. The progressive nature of the syndrome results in a further reduction of salivary
flow. Due to hyposalivation the patients suffer from progressive dental decay, dental
erosion, severe dry mouth complaints (i.e. eating and swallowing problems, lack of taste),
inflammation of the oral mucosa and lack of retention of removable dentures. Overall, this
can be qualified as a reduction in the quality of life. Until now no effective (palliative)
therapy to relieve dry mouth complaints is available. A recent case series study suggests
that an endoscopic technique (sialoendoscopy) is able to alleviate the symptoms of patients
suffering from SS. In this technique the ducts of the salivary glands are rinsed with saline
and cortisone and possible strictures are dilated. It is hypothesised that performing a
sialoendoscopic treatment will raise or restore (un)stimulated salivary flow levels and
improve the reported mouthfeel score.