Endoscopic Ultrasound Guided Coeliac Plexus Neurolysis for Cancer Pain

• Status: Not yet recruiting
• Trial end date: 2025-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive pathway that transmits the pain caused by the tumour. It can be with different approaches, such as percutaneously guided by fluoroscopy, echo-endoscopically or surgically with endoscopic approach being the more popular one in many centers equipped with echo-endoscopic services. The effect of CPN has been well established by some retrospective series. The overall response rate to CPN ranges from 70-90%, however, the analgesic effect is limited and up to roughly around 3 months. It is believed that the short-lasting analgesic effect is related to incomplete neurolysis by absolute alcohol injection.

Recently, radiofrequency ablation (RFA) of coeliac plexus has been introduced as another mode of CPN. So far, only one small single center randomized controlled trial (RCT) suggesting superior performance in favour to CPN using RFA. This result has to be validated and by a RCT with larger sample size. In addition, data concerning the quality of life (QOL) improvement and cost-effectiveness need to be further elucidated. Therefore, the aim of this study is to perform a RCT to look into these issues.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Hong Kong

Criteria

Inclusion Criteria:

• Age ≥18 year-old

• Patients who give informed consent to the study

• Suboptimal pain control with regular analgesics

• Inoperable cancer of pancreas, biliary system and liver (both primary or secondary)

Exclusion Criteria:

• Patients who refuse to give consent

• Patients aged <18 years

• EUS not possible due to:

• Problem related to scope insertion such as trismus, stenosis of the upper GI tract

• Coagulopathy with INR >1.5 or platelet count < 70

• Low oxygen saturation or extreme blood pressure render endoscopic procedure unsafe