Endothelin Receptor Function and Acute Stress

• Status: Active, not recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Augusta University
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Bosentan

Criteria

Inclusion Criteria:

• Men and premenopausal women (Ages 18-50 years old)

• Self-reported Black and White adults

• Lean adults (BMl <25 kg/m^)

• Obese adults (BMl > 30 kg/m^)

Exclusion Criteria:

• Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity)

• Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease

• Having evidence of pregnancy

• Using medications that affect vascular tone (i.e., nitrates, etc.)

• Postmenopausal women

• Uncontrolled hypertension

• Individuals who are on a restricted salt diet

• Having a history of chronic pain

• Having a history of rheumatoid arthritis

• Using medications that are contraindicated with bosentan (i.e. glyburide, cyclosporine)

• Liver dysfunction (which may be identified with the blood sample we take)