Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS
Status:
Recruiting
Trial end date:
2025-09-30
Target enrollment:
Participant gender:
Summary
Patients presenting with mild symptoms of acute ischemic stroke are common and account for
approximately half of all acute ischemic stroke. About 30% of patients with minor stroke have
a 90-day functional disability. Radiologically proven a large vessel occlusion (LVO) in
patients with minor stroke is a well-established predictor of poor outcomes, while the poor
outcomes following best medical management in patients with minor stroke with the underlying
presence of a LVO are mainly driven by the occurrence of early neurological deterioration
(END).
Considering the well-known strong association between lack of arterial recanalization and
END, endovascular therapy (EVT) appears as an attractive option to improve functional
outcomes for LVO-related patients with stroke with mild symptoms. Whether EVT is safe and
effective in patients with mild stroke with an LVO is currently debated, since these patients
were typically excluded from the pivotal EVT trials.
The current study aimed to further test the hypothesis that endovascular therapy would be
superior to medical management with respect to functional recovery among low NIHSS patients
caused by acute large-vessel occlusion in the anterior circulation.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital of Wannan Medical College