Overview

Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Status:
Active, not recruiting
Trial end date:
2021-11-30
Target enrollment:
Participant gender:
Summary
This pilot phase I trial studies the side effects of engineered donor stem cell transplant in treating patients with hematologic malignancies. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). Using T cells specially selected from donor blood in the laboratory for transplant may stop this from happening.
Phase:
Phase 1
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Antibodies
Antibodies, Monoclonal
Antineoplastic Agents, Immunological
Cyclophosphamide
Fludarabine
Fludarabine phosphate
Immunoglobulins
Lenograstim
Mechlorethamine
Melphalan
Nitrogen Mustard Compounds
Rituximab
Tacrolimus
Vidarabine