Enhanced Firefighter Rehab Trial: The Role of Aspirin in Preventing Heat Stress Induced Platelet Activation

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if aspirin taken by firefighters prevents platelets from becoming sticky when body temperature rises during work in protective clothing.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dave Hostler; University of Pittsburgh
• Collaborators: Eyemarker Systems, Inc; Federal Emergency Management Administration
• Treatments: Aspirin; Polystyrene sulfonic acid

Criteria

Inclusion Criteria:

1. Apparently healthy males and females aged 18-49 years

Exclusion Criteria:

1. History of heart disease, vascular disease, or sudden death including prior MI, coronary revascularization, congenital heart disease or history of stroke

2. Hypertension during screening: SBP>139 or DBP>89

3. Those who are taking medications that may be expected to blunt the physiologic response to a treadmill exercise test (e.g. beta blockers)

4. Prescription medication with known side effect of impaired thermoregulation

5. Positive pregnancy test at any time during the study

6. Resting ECG with clinical presentation suggesting coronary heart disease (e.g. pathologic Q wave)

7. Known history of gastrointestinal disease or disorder i.e. diverticulitis which creates a theoretical risk of the core temperature capsule becoming lodged in the digestive tract

8. Medications and supplements known to alter endothelial function (e.g. arginine, omega 3 fatty acids, NSAIDS, tobacco products. This exclusion may be disregarded for subjects willing to stop taking the supplement for the duration of the study

9. At the discretion of the study physician for any other medical condition or prescription medication

10. Known history of platelet dysfunction

11. Aspirin allergy or intolerance