Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
Our goal is to determine the acute effects of intranasal insulin on regional perfusion and
cognition of older adults. We propose a pilot study to examine the effect of a single dose of
intranasal insulin on regional vasoreactivity and cognitive functions in 30 subjects with
T2DM and 30 healthy controls >50 years old using a double blinded, placebo-controlled,
cross-over design.
Hypothesis 1: Intranasal insulin improves acutely regional perfusion and vasoreactivity in
older patients with T2DM as compared with placebo and compared with the control group.
Hypothesis 2: Intranasal insulin improves cognitive functioning including attention, memory
and executive function in diabetic patients as compared with placebo and compared with
control group.
Phase:
Phase 2
Details
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborators:
Boston University Joslin Diabetes Center Peking University University of Arkansas University of Massachusetts, Worcester University of Washington VA Boston Healthcare System Wake Forest School of Medicine Wake Forest University