Enhancing Adaptations to Exercise

• Status: Active, not recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Researchers are trying to understand how chronic inflammation affects muscle function and responses to exercise.They are also trying to determine if suppressing chronic inflammation using omega-3 fatty acids (n3-PUFA) restores skeletal muscle function and exercise responsiveness in older adults.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Collaborators: National Center for Research Resources (NCRR); National Institute on Aging (NIA)

Criteria

Inclusion criteria:

• Men and women between the ages of 20-35 years

• Men and women between the ages of 65-85 years

Exclusion criteria:

• Regular use of omega-3 nutritional supplements

• Diabetes or fasting plasma glucose > or equal to 126 mg/dL

• Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl)

• Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)

• Renal failure (serum creatinine > 1.5mg/dl)

• Chronic active liver disease (AST>144 IU/L or ALT>165 IU/L)

• Oral warfarin group medications or history of blood clotting disorders.

• international normalized ratio (INR) >2.01.5

• Smoking

• Pregnancy or breastfeeding

• Alcohol consumption greater than 2 glasses/day or other substance abuse

• Untreated or uncontrolled hypothyroidism

• Debilitating chronic disease (at the discretion of the investigators)

• Fish or shellfish allergy