Overview
Enhancing Attention in Adults With Compulsive Hoarding
Status:
Completed
Completed
Trial end date:
2011-04-01
2011-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Available data suggest that compulsive hoarders have cognitive deficits, particularly with sustaining attention that might contribute their hoarding symptoms.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
New York State Psychiatric InstituteCollaborator:
Hartford HospitalTreatments:
MethylphenidateCriteria
Inclusion Criteria:- Clinically significant compulsive hoarding (Proposed DSM-V criteria) that is principal
(i.e. currently most severe and needing of treatment) and has been present for at
least one year.
- At least moderate attentional difficulties.
- Able to provide consent.
- Patients can be on or off of serotonin reuptake inhibitors (SRIs) or serotonin and
norepinephrine reuptake inhibitors (SNRIs) but dose must be stable for 12 weeks prior
to study.
Exclusion Criteria:
- Currently taking any psychotropic medications other than SRIs or SNRIs.
- Presence of psychotic symptoms or lifetime history of schizophrenia, bipolar disorder
or other psychotic disorder.
- Current major depression is permitted if clearly secondary in importance to the
hoarding.
- Judged clinically to be at risk of suicide (suicidal ideation, severe depression or
other factors)
- Any cardiovascular abnormality that increases the risk of participation, including
significant history of cardiovascular disease or family history of sudden death.
- Any medical or neurological disorder that increases the risk of participation or that
is a medical contraindication for taking methylphenidate (e.g. glaucoma or Tourette's
syndrome).
- Current use of any drug that is contraindicated with methylphenidate (e.g. monoamine
oxidase inhibitors).
- Female patients who are pregnant or nursing.
- Current or previous treatment with methylphenidate or CBT for hoarding.
- Current ETOH/drug abuse or dependence disorder of dependency in the past 6 months.
- Individuals with mild cognitive impairments, dementia, or significant intellectual
deficits.