Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)
Status:
Completed
Trial end date:
2020-12-16
Target enrollment:
Participant gender:
Summary
This is a randomized, three-arm, open-label, clinical trial of malaria chemoprevention in
children with sickle-cell anemia (SCA) at a single site in Homa Bay, Kenya. The study will
enroll 246 children under 10 years of age, randomize participants 1:1:1 to one of three
malaria chemoprevention regimens, and follow participants monthly for 12 months in order to
record clinical episodes of malaria or SCA-related morbidity. Analyses will compare the
efficacy of each regimen to prevent malaria and SCA morbidity.