Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI bleeding related to stress gastropathy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mohamed Saad
• Collaborators: Abbott Nutrition; University of Louisville
• Treatments: Pantoprazole

Criteria

Inclusion Criteria:

• Age 18 years or older

• Admission to the medical ICU at University of Louisville Hospital or Jewish Hospital

• Expected need for mechanical ventilation > 48 hours

• No contraindication to EN within the first 24 hours after admission to the ICU

Exclusion Criteria:

• Evidence of active GI bleeding during current hospitalization prior to study entry

• Admission to ICU with primary diagnosis of burn injury

• Closed head injury or increased intracranial pressure

• Partial or complete gastrectomy

• Pregnancy or lactation