EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone
Status:
Recruiting
Trial end date:
2022-10-02
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the efficacy of combination therapy with omeprazole
and swallowed fluticasone vs fluticasone therapy and placebo in the treatment of Eosinophilic
Esophagitis (EoE) in children and adults. This study will be a double-blinded, randomized
controlled trial. The primary outcome measured will be histologic assessment of esophageal
tissue biopsies measuring number of eosinophils per high power field (eos/hpf). Secondary
outcomes will be endoscopic findings and symptomatic changes following therapy using
validated endoscopic scoring measures and participant surveys, respectively.