Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone
Status:
Withdrawn
Trial end date:
2017-07-20
Target enrollment:
Participant gender:
Summary
This study will compare response to treatment of Eosinophilic Esophagitis with montelukast vs
standard therapy fluticasone. Investigators hypothesize that montelukast is equally effective
in treating symptoms and histology of EoE when compared to fluticasone. The study will be
conducted at multiple sites with Medical College of Wisconsin as the coordinating site. After
identification and recruitment all patients will be randomized (provider blinded) to one of
two medications: montelukast 10mg po qday vs fluticasone 440mcg po bid. Patients will also
complete a pretreatment, 6 week therapy and 12 week therapy questionaire. They will then
undergo a repeat endoscopy to evaluate endoscopic and histologic response.