Overview

Eovist vs. Dotarem Healthy Volunteer MRI

Status:
Completed

Trial end date:
2015-09-01

Target enrollment:
0

Participant gender:
All

Summary

The purpose of this study is to evaluate changes in volunteer breath-holding capacity in response to gadoxetate disodium (Eovist) administration, compared with saline, and gadoterate dimeglumine (Dotarem). Healthy volunteers will be recruited from three study sites. These subjects will be given three, blinded, randomized injections while undergoing an MRI of their liver and holding their breath. During the scan, the subjects' oxygen saturation and heart rate will be closely monitored. Following the scan, the subjects will complete a questionnaire regarding the breath hold.

Phase:

Phase 4

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Duke University

Collaborators:

University of California, San Diego
University of Wisconsin, Madison

Treatments:

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

Criteria

Inclusion Criteria:

- normal renal function (serum eGFR >60)

Exclusion Criteria:

- renal impairment

- allergy to gadolinium-based contrast

- metallic implanted devices

- claustrophobia

- pregnant and lactating females