The purpose of this study is to evaluate changes in volunteer breath-holding capacity in
response to gadoxetate disodium (Eovist) administration, compared with saline, and gadoterate
dimeglumine (Dotarem). Healthy volunteers will be recruited from three study sites. These
subjects will be given three, blinded, randomized injections while undergoing an MRI of their
liver and holding their breath. During the scan, the subjects' oxygen saturation and heart
rate will be closely monitored. Following the scan, the subjects will complete a
questionnaire regarding the breath hold.
Phase:
Phase 4
Details
Lead Sponsor:
Duke University
Collaborators:
University of California, San Diego University of Wisconsin, Madison