Ephedrine vs. Nor Epinephrine Infusion in Preventing Hypotension After Spinal Anesthesia for Cesarean Section

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the study is to determine if norepinephrine is more effective as a continuous intravenous (IV) infusion compared to continuous IV ephedrine associated with crystalloid loading for maintaining blood pressure during a spinal anesthetic for a cesarean delivery. Prevention of low blood pressure has been shown to decrease nausea and vomiting during and after cesarean delivery under spinal anesthesia. For elective cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and morphine. This study plans to enroll 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of two groups.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Tunis El Manar
• Treatments: Anesthetics; Ephedrine; Epinephrine; Epinephryl borate; Norepinephrine; Pseudoephedrine; Racepinephrine

Criteria

Inclusion Criteria:

• The American Society of Anesthesiologists (ASA) Physical Status classification 1 and 2

• Pregnant women with singleton pregnancy

• Gestational age greater than 36 weeks

• Cesarean delivery under spinal anesthesia

Exclusion Criteria:

• Use of cardiac medication or medication for blood pressure control

• Cardiovascular disease

• Multiple gestation

• Gestation diabetes requiring insulin

• Refusal to be in study

• History of chronic opioid use (chronic pain syndrome)

• Emergent caesarean delivery for maternal and/or fetal distress

• Preeclampsia

• Eclampsia

• Progressive neurologic disease

• Infection at insertion site

• Allergy to local anesthetics, narcotics or other study medications