A prospective randomized double-blind clinical trial design will be used in a cohort of sixty
patients of both genders, physical status American Society of Anaesthesiologist (ASA) I and
II who will undergo lower limb amputation, will be enrolled into the present study. Patients
will divided randomly into two equal groups: Epidural Bupivacain-Calcitonin and fentanyl (BC)
Group and Bupivacain- fentanyl (BF) Group, comprising of 30 patients each.