Epidural Magnesium Sulfate for Post-thoracotomy Pain Control
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Pain after thoracotomy is very severe and may cause pulmonary complications. Thoracic
epidural analgesia has greatly decreased the pain experience and its consequences. However,
new ways of decreasing post-operative opioid drugs consumption is an important issue of
research. We aim to evaluate the effect of adding epidural magnesium sulfate to bupivacaine
and morphine on pain control and the amount of opioid consumption after thoracotomy. Eighty
patients undergoing thoracotomy at a tertiary cardiothoracic referral center will be enrolled
in a randomized double blind trial. Patients randomly will be allocated in two groups.
Bupivacaine (12.5 mg) plus morphine (2 mg) will be administered epidurally for all patients
at the end of operation. Patients in group I will be received epidural magnesium sulfate (50
mg) and patients in Group II will be received normal saline as an adjuvant. Visual analog
scale (VAS) score and the amount of morphine consumption will be measured during 24 hours
post-operation.
Phase:
N/A
Details
Lead Sponsor:
National Research Institute of Tuberculosis and Lung Disease, Iran