Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis
Status:
Unknown status
Trial end date:
2017-04-01
Target enrollment:
Participant gender:
Summary
Bronchiolitis is one of the main reasons for consultation in primary care and emergency
services, as well as the leading cause of hospitalization for lower respiratory tract
infection in children under two years. There is still no consensus on the medical management
of the disease, in clinical practice there is wide variability in the treatment with inhaled
drugs and / or oral bronchodilators, steroids, antihistamines despite the viral etiology of
the disease, which results in increased morbidity and a major economic benefit for all health
services.
Several studies are in relation to the management of bronchiolitis, one of which was made
during 2014 in the Naval Hospital of High Specialty which included 90 participants comparing
3 treatment. The treatments administered were: dexamethasone and epinephrine (Levogira) (ED),
hypertonic saline 3% (SSH 3%)and saline 0.9% ( SS 0.9%), finding that the handling of ED and
SSH 3% had lower rates of hospital admissions compared to the symptomatic management of SS
0.9%. Although the superiority of SSH3% and ED in relation to the use of SS 0.9% was
demonstrated, it was not possible to establish difference statistically significant between
them. Why it was considered necessary to continue the study focused on determining the
difference in the effectiveness of ED and SSH 3%. Therefore, the purpose of this
investigation is to determine whether there is a difference between the use of dexamethasone
and epinephrine versus hypertonic saline (3%).
Phase:
Phase 2
Details
Lead Sponsor:
Hospital General Naval de Alta Especialidad - Escuela Medico Naval