Epinephrine Nebulization Prior to Nasotracheal Intubation

• Status: Completed
• Trial end date: 2022-09-30
• Target enrollment: 0
• Participant gender: All

Summary

This randomised, prospective study performed in Ain shams university hospitals over 126 Patients ASA I and ASA II, trauma patients who suffered isolated mandibular fractures and necessitated nasal intubation during general anesthesia. The patients were randomly assigned to one of two equal groups: nasal Lidocaine drops followed by Oxymetazoline nasal drops group (OL) or Epinephrine mixed with Lidocaine as nebulization session (EL) group.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Epinephrine; Lidocaine; Oxymetazoline

Criteria

Inclusion Criteria:

• Cases with American Society of Anesthesiologists (ASA) classes I and II.

• Patients scheduled for elective oral isolated mandibular fracture fixation requiring nasotracheal intubation.

Exclusion Criteria:

• Nasal abnormality history (such as polyp , surgery or nasal trauma).

• Frequent epistaxis history.

• Patients suffering valvular heart disease, hypertension, ischemic heart disease or arrhythmias.

• Patients using drugs (anticoagulation therapy, non-steroidal anti-inflammatory drugs, and oral decongestants).

• Patients receiving medications known to alter the parameters under investigation including β-blockers, calcium channel blockers, or vasodilators.

• Patients known to have hypersensitivity to medications used in this study.