Epinephrine Sprayed on the Papilla Versus Sterile Water Sprayed on the Papilla for Preventing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography

• Status: Terminated
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This multicentre randomised controlled trial included patients aged >18 years with an indication for ERCP and naive major papilla. All patients received 100 mg of rectal indomethacin and 10 ml of either sterile water or a 1:10,000 epinephrine dilution. Patients were asked about PEP symptoms via telephone 24 hours and 7 days after the procedure.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
• Treatments: Epinephrine; Epinephryl borate; Indomethacin; Racepinephrine

Criteria

Inclusion Criteria:

• Age 18 years or older

• Patient with an indication for endoscopic retrograde cholangiopancreatography

• Patient without prior endoscopic retrograde cholangiopancreatography

• Patient who accept contact by telephone

Exclusion Criteria:

• Previous sphincterotomy

• Allergy to epinephrine or indomethacin

• NSAIDs use in the prior week

• Pancreatic cancer located in the head

• Chronic pancreatitis

• Renal failure (Cr >1.4 mg / dl)

• Indication for endotracheal intubation independent of endoscopic retrograde cholangiopancreatography

• Biliodigestive derivation

• Pregnant patients