Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has been a
well-recognized complication with significant morbidity and even mortality. A variety of
possible mechanisms has been suggested in the occurrence of pancreatitis, but papillary edema
caused by manipulations during cannulation or endoscopic treatment has received the most
attention. The papillary edema may cause temporary outflow obstruction of pancreatic juice,
and then increase ductal pressure, resulting in the occurrence of pancreatitis. Topical
application of epinephrine on the papilla may reduce papillary edema. Moreover, it is
reported that epinephrine sprayed on the papilla may be effective to prevent PEP. However, it
is still unclear that epinephrine sprayed on the papilla can prevent acute pancreatitis after
endoscopic retrograde cholangiopancreatography. We therefore designed a prospective
randomized trial to determine whether epinephrine sprayed on the papilla prevent PEP after
ERCP.