Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect Trial
Status:
Not yet recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
The use of peri-arrest bolus epinephrine (PBE) has emerged as a rescue strategy for
life-threatening hypotension in pediatric intensive care units (ICU) despite scant published
data supporting its use in this setting. As optimal dosing of PBE in this population is
unclear, we aim to determine if an initial dose of 0.5 mcg/kg versus 1.0 mcg/kg yields
differences in hemodynamic outcomes. The EPI Dose Study is a single-center, prospective,
randomized, double-blind, dose-effect trial measuring systolic blood pressure (SBP) before
and after PBE is given. We hypothesize that the 1.0 mcg/kg group will have more robust
increases in SBP.