The aim of the study is to assess the effect of eradication of gut microbiota on 1) glucose
metabolism including postprandial plasma responses of the incretin hormones GIP and GLP-1,
insulin, C-peptide and glucagon, 2) metabolomic profiles and resting energy expenditure (REE)
3) appetite, satiety, food intake, gastric emptying and gall bladder emptying, 4) levels of
markers of bone formation and resorption as well as serotonin, 5) markers of systemic
inflammation, and 6) on the (prospective) composition of bacteria in faeces, blood and
saliva. Thus, the overall objective is to provide detailed knowledge on the physiological
role of gut microbiota combined with bioinformatic analyses of the functional implications of
changes in bacteria composition on the level of both species and phylum.
Phase:
Early Phase 1
Details
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Collaborators:
Department of clinical microbiology, Rigshospitalet, Copenhagen Steno Diabetes Center Steno Diabetes Center Copenhagen University of Copenhagen