Eribulin Mesylate in Treating Patients With Recurrent Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

This phase II trial is studying how well eribulin mesylate works in treating patients with recurrent ovarian epithelial, primary peritoneal cavity, or fallopian tube cancer. Drugs used in chemotherapy, such as eribulin mesylate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)

Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed ovarian epithelial, primary peritoneal cavity, or fallopian tube cancer

• Recurrent disease after ≥ 1 prior therapy, meeting 1 of the following criteria:

• Platinum-resistant disease (progression-free interval < 6 months)

• Platinum-sensitive disease (progression-free interval ≥ 6 months)

• Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mmby conventional techniques OR ≥ 10 mm by spiral CT scan

• No known brain metastasis

• Life expectancy > 2 months

• ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%

• Absolute neutrophil count ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• WBC ≥ 3,000/mm^3

• Bilirubin normal

• AST and ALT ≤ 2.5 times upper limit of normal

• Creatine normal OR creatinine clearance ≥ 60 mL/min

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No prior invasive malignancy within the past 5 years except nonmelanoma skin cancer

• Stage IA or IB endometrial cancer within the past 5 years allowed provided patient is considered disease free

• No history of allergic reaction attributed to compounds of similar chemical or biological composition to E7389

• No HIV positivity

• No ongoing or active infection

• No cardiac arrhythmia

• No unstable angina pectoris

• No symptomatic congestive heart failure

• No psychiatric illness or social situations that would preclude study compliance

• No other uncontrolled intercurrent illness

• See Disease Characteristics

• Recovered from effects of recent surgery, radiotherapy, or chemotherapy

• No more than 2 prior cytotoxic therapies with no more than 1 non platinum, non taxane regimen

• No prior E7389

• More than 14 days since prior hormonal therapy

• More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C)

• More than 4 weeks since prior radiotherapy

• No concurrent antitumor hormonal therapy

• No other concurrent investigational agents

• No other concurrent anticancer agents or therapies

• No granulocyte colony-stimulating factors during the first course of study therapy